二、轉譯醫學研究 (I) 發展新的抗病毒方式應用到EB病毒相關惡性瘤的轉譯 醫學研究。 (II) 多發性骨髓瘤的病理發展 (III) V2R del279V突變在腎源性尿崩症的分子病理 (IV) EB病毒在間質性膀胱分子病理作用機轉 Selected Publications: 1. Ya-Lyn Chen, Cheng-Der Liu, Chi-Ping-Cheng, Bo Zhao, Hao-Jen Hsu, Chih-Long Shen, Shu-Jiun Chiu, Elliott Kieff, and Chih-Wen *Peng. 2014 Nucleolin is important for Epstein-Barr Virus Nuclear Antigen mediated episome binding, maintenance, and transcription. Proc Natl Acad Sci USA. 111(1):243-248.
2. Matthew R. Harter, Cheng-Der Liu, Chih-Lung Shen, Elsie Gonzalez-Hurtado, Zhi-Min Zhang, Muyu Xu, Ernest Martinez, Chih-Wen *Peng, and Jikui *Song. 2016 BS69/ZMYND11 is a potential EBNA2-targeting suppressor for EBV infection. PLoS Pathog 12(2): e1005414. 3. Chih-Lung Shen, Cheng-Der Liu, Ren-In You, Yung-Hao Ching, Jun Liang, Liangru Ke, Ya-Lin Chen, Hong-Chi Chen , Hao-Jen Hsu, Je-Wen Liou, Kieff Elliott, and Chih-Wen *Peng. 2016 Ribosomal Protein L4 is essential for Epstein-Barr virus Nuclear Antigen 1 functions. Proc. Natl. Acad. SciUSA. Feb 23;113(8):2229-34.
4. Jhang JF, Hsu YH, Peng CW, Jiang YH, Ho HC, Kuo HC Epstein-Barr Virus Presence As A Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis/Bladder Pain Syndrome. J Urol. 2018 Sep;200(3):590-596
5. Shen CL, Huang WH, Hsu HJ, Yang JH, *Peng CW. GAP31 from an ancient medicinal plant exhibits anti-viral activity through targeting to Epstein-Barr virus nuclear antigen 1. Antiviral Res. 2019 Apr;164:123-130
6. Liu CD, Lee HL, Peng* CW.B cell specific transcription activator PAX5 recruits p300 to support EBNA1-driven transcription. J Virol. 2020 Jan 15. pii: JVI.02028-19.
7.Jia-Fong Jhang, Cheng-Der Liu, Yung-Hsiang Hsu, Chien-Chin Chen, Hsiang-Chin Chen, Yuan-Hong Jian, Wang Chen Wu, Chih-Wen *Peng, Hann-Chorng *Kuo. EBV infection mediated BDNF expression is associated with bladder inflammation in interstitial cystitis/bladder pain syndrome with Hunner's lesion. J Pathol March 2023;259:276–290.